Regulation of Spreading Depression Events in Brain Slices by Astrocyte Metabolism By
نویسنده
چکیده
of Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Biomedical Sciences The University of New Mexico Albuquerque, New Mexico May 2011
منابع مشابه
Electrophysiological characteristics of hippocampal CA1 neurons after spreading depression-triggered epileptic activity in brain slices
Introduction: A close link between spreading depression (SD) and several neurological diseases such as epilepsy could be demonstrated in many experimental studies. Epilepsy is among the most common brain disorders. Despite a large number of investigations, its mechanisms have not been yet well elucidated. Hippocampus is one of the important structures involved in seizures. The aim of this st...
متن کاملنقش مهار منتشر شونده قشری بر القای تشنج در هیپوکمپ موش صحرایی نر
Background & Aims : Spreading depression is a pathophysiological phenomenon that is initiated by a self-propagating depolarization wave with a short-term excitability and is followed immediately by an inhibitory phase and then continues with a long-term secondary excitability. Spreading depression has a critical role in many disorders such as migraine and seizures . The purpose of this stud...
متن کاملDifferent mechanisms promote astrocyte Ca2+ waves and spreading depression in the mouse neocortex.
Cortical spreading depression (CSD) is thought to play an important role in different pathological conditions of the human brain. Here we investigated the interaction between CSD and Ca2+ waves within the astrocyte population in slices from mouse neocortex (postnatal days 10-14). After local KCl ejection as a trigger for CSD, we recorded the propagation of Ca2+ increases within a large populati...
متن کاملEffect of Cannabinoid Receptor Activation on Spreading Depression
Objective(s) The objective of this study was to evaluate the effect of cannabinoid on cortical spreading depression (CSD) in rat brain. Cannabis has been used for centuries for both symptomatic and prophylactic treatment of different types of headaches including migraine. CSD is believed to be a putative neuronal mechanism underlying migraine aura and subsequent pain. Materials and Methods T...
متن کاملThe Neuroprotective Effects of Long-Term Repetitive Transcranial Magnetic Stimulation on the Cortical Spreading Depression-induced Damages in Rat’s Brain
Introduction: Cortical Spreading Depression (CSD) is a propagating wave of neural and glial cell depolarization with important role in several clinical disorders. Repetitive Transcranial Magnetic Stimulation (rTMS) is a potential tool with preventive treatment effects in psychiatric and neuronal disorders. In this paper, we study the effects of rTMS on CSD by using behavioral and histological a...
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تاریخ انتشار 2011